Anthology series set in room 104 of a seemingly average American motel, each time telling a different story of the assorted guests who pass through, which can range from funny and fantastical to dramatic and horrifying.
Cast:Jennifer Lafleur , Jon Bass , Jenny Leonhardt , Kristina Harrison , Lily Gladstone , Susanna Harter , Keir Gilchrist , Karan Soni , Amy Landecker , Clark Duke , Philip Baker Hall , Jay Duplass , Melonie Diaz , Dendrie Taylor , Konstantin Lavysh , Sameerah Luqmaan-Harris , Adam Foster , Natalie Morgan
An estranged brother and sister reunite at the site of their future joint investment - the hotel where the Room 104 will eventually be located. However, things soon take a grim supernatural turn.
In this comedic episode, the tired lifelong caretaker of an exotic animal, a gorilla that paints and whose works some consider art, meets in Room 104 with a woman who wants to take the beast off his hands. However, neither of them can control nature.
On the advice of his doctor, a man with a chronic skin ailment sequesters himself in room 104 in hopes that he might be cured. Each day, he leaves video messages to the doctor, detailing the progress of his self-treatment which gets more and more extreme as the ailment worsens in disturbing ways.
An apocalyptic event caused by a rogue planet has doomed Earth. A young girl on the run from her crazy father befriends a pregnant psychic woman who tells her about a safe place where they can hide.
A musician girl trying to play music and sing in room 104 is haunted by a ghost girl.
In this documentary episode, father and son artists Jimmy Ray Flynn and Gianni Arone create a work of art in Room 104, where they open up about their relationship, creative process and Gianni's history with addiction and mental illness.
A dying man summons his estranged children, who hate each other, to Room 104 for one final mysterious confrontation. His daughter wants nothing to do with it, but he warns her that her brother will use her inaction to his own ultimate advantage.
Left alone by her parents in Room 104, a bored neglected teenage girl makes a series of prank calls where she pretends to be a jail bait seductress tempting married men and even offering them phone sex, until one of them tests her brazen alter-ego.
The star of a beloved cheese 1970s television horror show called Night Shift agrees to talk to a goth fangirl for her podcast in Room 104 about the origins of the cult TV program. However, when his old partner from the show also arrives, old wounds lead to new terror.
A young woman sells her soul to live a life of earthly pleasures and is forced to reckon with her decision decades later.
While on a layover from collecting a rare botanical specimen, a scientist wakes to find herself inside a lush, rapidly growing jungle.