Follows the lives and loves of four close, but very different, sisters of the Reed family living in Winnetka, Illinois.
Genre: Drama
Cast:Swoosie Kurtz , Patricia Kalember , Sela Ward , Elizabeth Hoffman , Garrett M. Brown , Julianne Phillips , Heather McAdam , Jill Novick , Sharon Martin , Ed Marinaro , Riff Regan , Dustin Berkovitz , Ryan Francis , Tasia Schutt , Ashley Judd , Sheila Kelley , Robert Klein , Nora Dunn
Frankie and Mitch battle in court over their son; Cat trains Alex for a marathon; the first lady seeks Teddy's services.
Seeking to avenge the attack on Cat, Teddy interferes in the investigation; Reed joins a religious cult.
Teddy overreacts when Cat's attacker makes bail; Frankie prepares for a date with a man she met over her computer; Alex wants John on her show.
The Sweet Sixteen burns down, a TV producer offers Alex a hot opportunity, and things heat up between Mitch and Teddy
Teddy falls for Detective Falconer (George Clooney); Georgie and John's son is dating an older girl, drinking and failing school.
Simon Bolt visits; Alex and Truman plan a surprise party for Beatrice; Frankie has second thoughts about hiring Trevor.
Frankie helps her father's one-time mistress (Diane Ladd), now a homeless woman; Teddy hires Bolt as her assistant.
Falconer learns Bolt is wanted in London for embezzlement; Georgie and family try to help Trevor overcome his rebellious phase.
The sisters prepare for Christmas; Trevor misbehaves; Alex's show is canceled; Teddy bolsters Falconer after his son's death; guest Robert Klein.
A disastrous introduction to Alex's family prompts second thoughts about Al; Falconer's work-related injury alerts Teddy to the risks of dating a cop.
Depressed and confused, Georgie contemplates suicide while Trevor is at the rehabilitation center and John and Evan are away.
Alex dates a doctor (John Calvin) who makes her miss Al; Teddy believes an art-gallery owner's accidental death was murder.
Trevor runs away from the rehabilitation center; Teddy doubts Falconer's innocence in a police-brutality case; guests Tammy Lauren, Nora Dunn.
Teddy and Falconer prepare for his police brutality trial; Alex tries to convince everyone that her assistant has ulterior motives.
Teddy summons the courage to propose to Falconer; Alex and Al marry; Evan plots to reunite Georgie and John; Truman asks Beatrice for a divorce.
The sisters learn they might have a half-sister (Jo Anderson); Mitch encourages Frankie to date; Teddy fears she is losing Falconer to his ex-wife.
The sisters await results of their blood tests; Alex and Al await the verdict in his tax-fraud case; Cat has her first date since the attack.
Teddy spots nephew Trevor living on the streets of Chicago; Alex invites Norma's parents to Winnetka.
Pregnant Reed returns to learn that Alex may have cancer; Falconer is assigned to protect Teddy from a stalker.
Naomi Judd appears on Alex's talk show, then must deliver Reed's baby; eloping Teddy and Falconer fly into a storm.