From the hills of West Virginia, Amos McCoy moves his family to an inherited farm in California. Grandpa Amos is quick to give advice to his three grandchildren and wonders how his neighbors ever managed without him around.
Cast:Walter Brennan , Richard Crenna , Kathleen Nolan , Tony Martinez , Michael Winkelman , Lydia Reed , Andy Clyde , Madge Blake , Janet De Gore , Jon Lormer , Butch Patrick , Willard Waterman , Stanley Farrar , Robert Foulk , Marjorie Bennett , Eva Norde , Eddie Quillan , Olan Soule
Grandpa, Luke, Kate, Hassie and Little Luke McCoy travel from Smokey Corners, West Virginia to California. They take over an inherited farm and everyone loves it, but Grandpa who has trouble adjusting to the new place.
Grandpa gets into an egg feud with a rival egg salesman. He makes money, but the rest of the family suffers when Hassie wants to date the rival's son.
Grandpa and Luke need a new gun for a shooting contest. Kate needs a new dress to be inducted into the PTA. There's just enough money in the cookie jar for one of them.
The McCoys find out that they are three months behind on their mortgage payments and will lose the farm if they can't come up with the money. Grandpa fears that he will have to sell a 200 year old flintlock family rifle to get the payment.
Kate wants to discipline Hassie and Little Luke for bad grades and skipping school, but Grandpa thinks she is being too tough. So Kate lets Grandpa takes over raising the kids.
Grandpa's innate honesty saves the day when a dishonest real estate speculator tries to buy five unproductive acres of the McCoys' land for considerably less than its actual value.
Kate pointedly tells Luke that he is welcome to go fishing with Grandpa and Mac Maginnis and to do whatever he wishes for several nights thereafter, but Grandpa steps in to make amends when he realizes that Luke's "freedom" is causing a genuine strain on their still-young marriage.
The Farmer's Association is having it's fall dance and Grandpa doesn't want to take Flora MacMichael until Little Luke tells him about the box supper that Flora is bringing.
Grandpa and George MacMichael compete to win the fishing contest. The only problem is that both of them are better at cheating than fishing.
Grandpa pretends to be able to read so he can vote against an uppity female politician.
Grandpa gets struck with jealousy because of Flora MacMichael and tries to take it out on her apple tree.
Grandpa and Luke jeopardize Kate's chances to be named to a church committee when they unwittingly allow a Las Vegas gambling house to advertise on the McCoys' barn.
Much to Grampa's consternation, George wants to join a private club known as the Loyal Order of the Mystic Nile.
Grampa's vanity gets the best of him when he refuses to acknowledge that he needs eyeglasses to pass the vision test for his new California driver's license.
A multi-talented photographer obtains the McCoys' permission to take pictures of their farm, but Luke becomes jealous when he seems to be focusing most of his attention on Kate.
Grandpa has Luke prepared for the worst when it is learned that Kate's mother is coming for a visit, but everyone is surprised when she arrives and repeatedly chides Kate for being insufficiently attentive to Luke's needs.
Amos invites their old neighbors to California for a visit including Luke's old girlfriend Elvira. Kate tries to hide her jealousy during the reminiscing of old times.
When some of Little Luke's classmates tease and bully him about his "hillbilly" roots, Grandpa steps in to teach them about the perniciousness of prejudice.
The retirement of the postman convinces Luke and Kate that Grandpa Amos should take it easier. It backfires when Grandpa instead works too hard and ends up bedridden.
Grampa breaks up Flora's romance, and is forced to propose to her.
After one full year of marriage, Luke and Kate finally get to go on their honeymoon.
Luke McCoy is tricked into buying a swimming pool.
Kate's rich Uncle Dave stays with the McCoys for the weekend.
Feeling that he's been forgotten on his birthday, Grampa runs away from home.
Grampa has a cold, but he doesn't trust the new doctor - or any doctor, for that matter.
After Grampa refuses to give him a raise, Pepino quits and goes to work for neighbor George MacMichael.
Kate creates a successful dress alteration business at home, much to the consternation of Grampa and the local tailor.
Grampa is in desperate need of character witnesses to testify on his behalf at his parking ticket trial.
The McCoys teach a wealthy couple the joys of simple living.
Grampa tries to stop a marriage-minded widow from chasing George.
Luke wants to modernize the farm, but Grampa is against change.
Grampa has his heart set on joining the town's volunteer fire department.
Little Luke worships his Grandpa Amos, but when he gets in trouble at school for using Grandpa's colorful language and telling lies the rest of the family tells Amos to set a better example for Little Luke. Amos tries his best to change his ways, but after a week he can't stand it anymore and reverts to his old habits. When Little Luke's teacher brings him home from school after a serious incident, Amos faces a hard choice: continue to be his grandson's hero or admit that he's not perfect.
Hassie refuses to accept a date with the homeliest boy in class.
Scandal erupts when a 30-year-old photo of Flora clad in a scanty swimsuit winds up in a local publication.
Grampa wagers Kate's prize hen, Jenny, on Little Luke winning a corn-eating contest.
Grampa secretly joins an over-sixties club known as the "Young Old Timers".